What is organ donation?
Organ donation is the process of a person donating their organs for transplant. These are given to someone with damaged organs that need to be replaced.
An organ transplant may save a person's life, or significantly improve their health and quality of life.
The need for donors
Black people are three times more likely to develop kidney failure than the general population, and the need for donated organs in Asian communities is three to four times higher than in the general population.
There is no age limit to becoming a donor. A person's physical condition, not age, is the deciding factor. Specialist healthcare professionals decide in each case which organs and tissue are suitable. Organs and tissue from people in their 70s and 80s are transplanted successfully.
Most people waiting for a donated organ need to have a kidney, heart, lung or liver transplant. One donor can help several people because a single donor can donate a number of organs, including:
- small bowel
Tissues that can be donated include:
- the cornea (the transparent layer at the front of the eye)
- heart valves
All donors have the choice of which organs and tissues they wish to donate. Read more about what organs can be donated.
How to donate
Even though there is a significant number of people on the register, most people will not die in circumstances that allow them to donate their organs. This makes it more important that as many people as possible join the register.
You should discuss your wishes with your family and medical staff so they are aware.
Checking for a match
When an organ becomes available for donation, it is checked to make sure it is healthy. The blood and tissue type of both donor and recipient are also checked to ensure they are compatible. The better the match, the greater the chance of a successful outcome.
People from the same ethnic group are more likely to be a close match. Those with rare tissue types may only be able to accept an organ from someone of the same ethnic origin. This is why it is important that people from all ethnic backgrounds register to donate their organs.
Types of donation
There are three different ways of donating an organ. These are known as:
- donation after brain stem death
- donation after cardiac death
- live organ donation
These are described below.
Donation after brain stem death
Most organ donations are from brain stem dead donors. This means the donor has been confirmed brain stem dead following a severe brain injury. The circulation is supported by artificial ventilation until the donated organs have been removed.
Heartbeating donations have a high success rate because the organs are supported by oxygenated blood until they are removed.
Donation after cardiac death
Organs and tissue can also be donated after cardiac death.
In these cases, the organs must be removed within a few minutes of the heart stopping to prevent them being damaged by a lack of oxygenated blood.
Live organ donation
A live organ donation usually involves one family member donating an organ to another family member. The relative is usually blood-related, most commonly a parent, although it could be a partner.
Following changes in the law, it is now possible to be an altruistic donor. Altruistic donors are unrelated to the patient but become donors as an act of personal generosity.
Kidney donations are often made from living donors, as a healthy person can lead a normal life with only one working kidney.
Read more information about living donation.
Organ donation process
In the event of your death, there is a chance your organs could help save someone else's life.
The donation process
If appropriate, brain stem death testing will be carried out by hospital staff to confirm the patient is dead. Alternatively, a joint decision may be made by medical staff, nursing staff and the patient's relatives that although brain stem death has not occurred, the prospect of survival is so low it is not helpful to continue with artificial ventilation.
If the family agrees to organ donation, the specialist nurse must ensure medical tests are carried out, such as blood group and tissue type matching. They will also look at the donor's medical history and ask the family some questions about them. This will help confirm whether or not the organ donation can take place.
You can also read real stories about organ donation from people who have received organs, and of families who have donated their loved ones' organs.
Organ donation and medical conditions
In most circumstances, having a medical condition does not necessarily prevent a person from becoming an organ or tissue donor. The decision about whether some or all organs or tissue are suitable for transplant is made by a healthcare professional, taking into account your medical history
There are three conditions where organ donation is ruled out completely. A person cannot become an organ or tissue donor if they have had:
- cancer that has spread in the last 12 months
- a severe or untreated infection
- Creutzfeldt-Jakob Disease (CJD), a rare condition that affects the nervous system and causes brain damage
A team of specialist surgeons is called to the donor's hospital to remove and preserve the organs for transport to the transplant unit. Timing is crucial because certain organs need to be transplanted within four to six hours.
During the operation, the surgeon will make a final decision about whether the organs are healthy and suitable to be transplanted. If all is well, the organ is received at the transplant unit and transplanted immediately.
The shortage of organs has led to more people receiving organs from living donors. Although this involves carrying out major surgery, results are often very successful.
Before a living donor transplant can take place, strict regulations must be met and there must be a thorough process of assessment and discussion.
See below for more information about the regulations and assessment process.
Living organ donations
Kidneys are the most common organ donated by a living person. This is because it is possible for a healthy person to lead a completely normal life with only one working kidney. Nearly one in three of all kidney donations are from living donors.
It is also possible for part of a liver to be transplanted, and in some circumstances it may also be possible to donate a segment of lung. In a very small number of cases, part of the small bowel has also been transplanted.
Who can be a living donor?
Close relatives are most likely to donate an organ to a loved one. However, it is possible for a donation to be made by someone not related or connected to the recipient.
Living donation will only go ahead if the blood group and the tissue type of donor and recipient are compatible.
Read about how organ donation works for more information about ways an organ can be donated.
Success and survival rates
Kidneys from a living donor last longer than those donated from someone who has died.
Research has shown that in people who receive a kidney from someone who has died:
- 80-90% of kidneys will still be working after one year
- 77% of kidneys will still be working after five years
- 58% of kidneys will still be working after 10 years
However, in kidney transplants where the kidney is donated from a living donor:
- 95% of kidneys will still be working after one year
- 84% of kidneys will still be working after five years
- 66% of kidneys will still be working after 10 years
Survival rates are also increased for people who receive kidneys from live donors rather than from donors who have died.
The survival rates of patients who receive kidney transplants from live donors are:
- 94% will still be alive five years after the transplant
- 85% will still be alive 10 years after the transplant
For those who receive kidney transplants from donors who have died:
- 85% will still be alive five years after the transplant
- 61% will still be alive 10 years after the transplant
After the organ donor and the recipient of the donation have been assessed by the transplant team, an independent assessor from the HTA will assess the donor. They will make sure that all the legal requirements for the donation have been met.
Organ donation can lead to life-saving transplants or help improve a person's health and quality of life. It is also possible to donate tissue.
There are several different types of organ transplants and the reasons why they may be used can vary. Organs that can be donated include:
- small bowel
A number of other body parts can also be donated (see tissue donation).
A kidney can provide a better quality of life to someone who has end-stage renal failure (ESRF). Renal failure is where the kidneys stop working properly.
Kidney transplants give better long-term survival rates and quality of life than dialysis (where some of the kidney's functions are artificially replaced). Kidneys used for transplant can come from a living person or from someone who has died.
The demand for donated kidneys is higher than for any other organ. More than 1,599 kidney transplants were carried out during 2011-12. The number of living donor kidney transplants being performed is also increasing, with 1,009 kidney donations from living donors being carried out during the same period.
Read more information about kidney transplants.
A liver transplant is often considered for people with end-stage liver disease. In around 86% of cases, transplanted livers still function well a year after surgery.
In 2011-12, a total of 726 liver transplants were carried out in the UK. For adults, the average waiting time for a liver transplant is around 142 days, and for children it is about 78 days.
Read more information about liver transplants.
Most heart transplants are carried out on people with severe heart failure caused by coronary heart disease or cardiomyopathy (diseased heart muscles) who can no longer be helped by medication or other surgery. The survival rate after one year of having a heart transplant is approximately 85%.
Read more information about heart transplants.
Lungs can be damaged by illnesses such as cystic fibrosis (where the lungs become clogged with thick, sticky mucus), or respiratory conditions such as chronic obstructive pulmonary disease (COPD), which are often the result of smoking.
Patients are considered for lung transplantation when their lung function cannot be significantly improved by medical therapy or surgery. Lung transplants have a 77% success rate one year after surgery, and heart-lung transplants have a 73% success rate.
Around 175 lung transplants are carried out in the UK each year. The average waiting time for a lung transplant is around 412 days.
Read more information about lung transplants.
A small bowel transplant (intestinal transplant) is usually recommended if there is not enough bowel left to absorb nutrition (short bowel syndrome), and when the patient is having difficulty with total parenteral nutrition (TPN). TPN is where nutrition is given intravenously (through a vein).
Small bowel transplants are often performed at the same time as a liver and pancreas transplant. This is called a multivisceral transplant.
Small bowel transplants are fairly uncommon. Only 22 intestinal transplants were carried out in 2011-12. On average, patients wait six months for a transplant of this type.
Read more information about a small bowel transplant.
A successful pancreas transplant is the only treatment that can restore complete insulin independence and blood sugar levels in patients with type 1 diabetes.
In 2011-12, 37 pancreas only and 173 pancreas and kidney transplants were carried out in the UK. The average waiting time for a combined pancreas and kidney transplant for an adult is around 278 days.
Read more information about pancreas transplants.
Unlike organs, tissue can be donated up to 48 hours after the heart has stopped beating. The tissue can be used to treat a wide variety of conditions, some of which may be life-threatening.
The most common tissues that can be donated are:
- the cornea (the transparent layer of tissue at the front of the eye)
- heart valves
It is possible to retrieve tissue from a donor up to 48 hours after a person has died. This is very useful because it allows tissue to be screened for possible infectious agents, and enables a pool of available tissue to be established.
Corneas can be transplanted to restore the sight of a person who has an eye condition or eye injury. Patients closest in age to the donor are usually selected as recipients, wherever they live in the country.
Cornea transplants can be carried out under either a general or local anaesthetic.
Read more information about cornea transplants.
Heart valves can be used to help children born with heart defects. They are also used for adults with diseased or damaged valves.
Bone can be used to help improve or restore mobility. Bone grafts can also be used in a variety of orthopaedic procedures (those that involve muscles, joints, tendons, ligaments and nerves), including joint replacements and spinal surgery.
Bone transplants can also prevent a limb from being amputated (surgically removed) in people with bone cancer.
Skin can help save the lives of severe burns victims. A skin graft helps reduce pain and prepares underlying tissue for later treatment. It also helps reduce scarring. However, it can take a number of grafts to treat a severely burned patient successfully.
Tendons are tough, flexible tissues found throughout the body which connect muscles to bone and cartilage. Donated tendons are usually used to reconstruct injured knees in young people, usually following sports injuries.
Cartilage is used to help reconstruct parts of the body following injury or during joint replacement surgery.
Common reasons for cartilage transplant include injury or wear caused by disease, such as osteoarthritis (a common type of arthritis that causes inflammation of the bones and joints).